Awards and Publications

Awards

• Clinical Research Nutrition Unit Award, 2000
• AB Clinical Research Training Program Award (NIH) 1999
• ACOG/Parke-Davis Research Award 1998
• ASRM/Organon Research Award 1998
• Resident Research Award 1993
• Meade Johnson Junior Fellow Award 1993
• Ortho Pharmaceutical Creog Award 1991

Publications

1. Knochenhauer ES, Azziz R, Current Concepts in the Diagnosis and Treatment of the Hirsute Patient. Current Opinions in Obstetrics & Gynecology. 1995, 7(5):344-350.

2. Knochenhauer ES. A Case Discussion of Hyperandrogenism. Collected Letters, International Correspondence Society of Obstetrics & Gynecologists. 1995, 37(8) 5-8.

3. Knochenhauer ES, Cortet-Rudelli C, Cunningham RD, Conway-Myers BA, Dewailly D, Azziz R. Carriers of 21-Hydroxylase Deficiency Are Not At Increased Risk For Hyperandrogenism. 1997 JCEM, 82(2):479-485.

4. Conway-Myers BA, Kretzer PA, Knochenhauer ES, Steinkampf MP. Effects of Gamete/Embryo Coculture Using Homologous Tubal Cells on Human In Vitro Fertilization and Preimplantation Embryo Development. Fertility and Sterility, 1998 (submitted).

5. Knochenhauer ES, Boots LR, Potter HD, Azziz R. Differential Binding of Estradiol (E2) and Testosterone (T) to Sex Hormone-Binding Globulin (SHBG) in Relation to Circulating E2 Levels. 1998, JRM, 43(8):665-670.

6. Knochenhauer ES, Azziz R. Evaluation of Infertility: A Cost Effective Approach. References en Gynecologie Obstetrique, 1998, 3(5):315-20.

7. Knochenhauer ES, Boots LR, Key TJ, Azziz R. Prevalence of Hirsutism Among Unselected Black and Caucasian Women in the Southeastern United States: A Prospective Study. JCEM, 1998, 83(9):3078-3082.

8. Azziz R, Waggoner WT, Ochoa T, Knochenhauer ES, Boots LR, Idiopathic Hirsutism: An Uncommon Cause of Hirsutism in Alabama. Fertility and Sterility, 1998, 70(2):274-278.

9. Moran C, Knochenhauer, ES, Azziz R. Non-classic Adrenal Hyperplasia in hyperandrogenism: A Reappraisal. J Endocrinol Invest, 1998, 21:707-720.

10. Conway-Myers BA, Knochenhauer ES, Steinkampf MP. Co-culture in Assisted Reproductive Technology. Assisted Reproduction, 1999, 9(1):23-30.

11. Azziz R, Hincapie LA, Knochenhauer ES, Dewailly D, Fox L, Boots LR. Screening for 21-hydroxylase deficient non-classic adrenal hyperplasia among hyperandrogenic women: A prospective study. Fertil Steril, 1999, 72:915-25

12. Huerta R, Dewailly D, Decanter C, Knochenhauer ES, Boots LR, Azziz R. Serum 11β-hydroxyandrostenedione and Δ5 –androstenediol as markers of adrenal androgen production: Studies in 21-hydroxylase deficient non-classic adrenal hyperplasia. Fertil Steril 1999, 72:996-1000.

13. Moran C, Knochenhauer ES, Boots LR, Azziz R. Adrenal Androgen Excess in Hyperandrogenism: Relationship to Age and Body Mass. Fertil Steril, 1999, 71:671-4.

14. Speiser PW, Knochenhauer ES, Dewailly D, Fruzzetti F, Marcondes JAM, Azziz R. A multicenter study of women with non-classical congenital adrenal hyperplasia: relationship between genotype and phenotype. Mol Genet Metab, 2000, 71:527-534.

15. Knochenhauer ES, Black V, Hines G, Conway-Myers BA, Azziz R. Examination of the chin or lower abdomen only for the prediction of hirsutism. Fertil Steril , 2000, 74:980-3

16. Moran C, Azziz R, Carmina E, Dewailly D, Fruzzetti F, Ibanez L, Knochenhauer ES, Marcondes JAM, Mendonca BB, Pignatelli D, Pugeat M, Rohmer V, Speiser PW, Witchel SF. 21-hydroxlase deficient non-classic adrenal hyperplasia is a progressive disorder: A multicenter study. Am J Obstet Gynecol, 2000, 183:1468,1474

17. Huerta R, Dewailly D, Decanter C, Knochenhauer ES, Boots LR, Azziz R. Adrenocortical hyper- responsivity to ATCH: A mechanism favoring the normal production of cortisol in 21- hydroxylase deficient non-classic adrenal hyperplasia. Fertil Steril, 2000, 74:329-34.

18. Nichols J, Knochenhauer E, Fein SH,Nardi RV, Marshal D, and the Repronex SC Ovulation Induction Study Group. Subcutaneously administrated Repronex in oligo-ovulatory female patients undergoing ovulation induction is as effective and well tolerated as intramuscular human menopausal gonadotropin treatment. Fertil Steril,2001, 76(1): 58-66.

19. Farah-Eways LA, Reyna R, Knochenhauer ES, Bartolucci AA, Azziz R. Glucose Action and Adrenocortical biosynthesis in women with polycystic ovarian syndrome. Fertil Steril 2004 , 81(1) ;120-5.

20. Azziz R, Sanchez LA, Knochenhauer ES, Moran C, Lazenby J, Stephens KC, Taylor K, Boots LR. Androgen excess in women: Experience with over 1000 consecutive patients. J Clin Endocrinol Metab. 2004 89(2):453-62.

21. Azziz R, Woods KS, Reyna R, Key TJ, Knochenhauer ES, Yildiz BO.The prevalence and features of the polycystic ovary syndrome in an unselected population.J Clin Endocrinol Metab. 2004 Jun;89(6):2745-9.

22. Azziz R, Farah LA, Moran C, Knochenhauer ES, Potter HD, Boots LR.Early adrenarche in normal prepubertal girls: a prospective longitudinal study. J Pediatr Endocrinol Metab. 2004 Sep;17(9):1231-7.

23. Chang WY, Knochenhauer ES, Bartolucci AA, Azziz R. Phenotypic spectrum of polycystic ovary syndrome: clinical and biochemical characterization of the three major clinical subgroups.Fertil Steril. 2005 Jun;83(6):1717-23.

Publications:  Abstracts

Knochenhauer ES, Potter HD, Lazenby AJ, Azziz R. Is Heterozygosity for 21-Hydroxylase (21-OH) Deficient Classic (CAH) Adrenal Hyperplasia a Risk Factor for Hyperandrogenism? American Society for Reproductive Medicine, 1995, Seattle, Washington, Oct 7-12 (Oral Presentation, PG-87)

Knochenhauer ES, Conway-Myers BA, Kretzer PA, Steinkampf MP. Effects of Gamete/Embryo Co-culture (CC) using Fresh versus Frozen Homologous Tubal Cells on Human in Vitro Fertilization and Preimplantation Embryo Development. American Society for Reproductive Medicine, 1995, Seattle, Washington, Oct. 7-12 (Poster Presentation, P-26)

Knochenhauer ES, Conway-Myers BA, Kretzer PA, Steinkampf MP. Effects of Gamete/Embryo Co-culture (CC) When Utilized from Day 0 (Day of Retrieval) Compared to Day 1 (Day 0 standard media) using Homologous Tubal Cells on Human in Vitro Fertilization and Preimplantation Embryo Development. Society For Gynecologic Investigation, 1996, Philadelphia, PA, March 20-23 (Poster Presentation)

Cortet-Rudelli C, Knochenhauer ES, Cunningham RD, Boots LR, Dewailly D, Azziz R. Heterozygosity for 21-Hydroxylase (21-OH) Deficient Classic (CAH) Adrenal Hyperplasia May Be A Risk Factor for Hyperandrogenism. International Congress of Endocrinology, 1996, San Francisco, Ca, June 12-15 (Oral Presentation, OR26-7).

Azziz R, Knochenhauer ES. Evaluation of Infertility: A Cost Effective Approach. 10th World Congress on IVF, 1997, Vancouver, B.C., Canada, May 24-28 (Oral Presentation).

Azziz R, Steinkampf MP, Knochenhauer ES. Is ART the Best Treatment for Infertile Couples? Not So! 10th World Congress on IVF, 1997, Vancouver, B.C., Canada, May 24-28 (Oral Presentation).

Knochenhauer ES, Waggoner WT, Azziz R, Carmina E, Dewaily D, Fruzzetti F, Ibanez L, Marcondes JAM, Mendonca BB, Rohmer V, Speiser PW, Zacur HA. Clinical Features and Genotype of 21-hydroxylase (21-OH) Deficient Non-classic Adrenal Hyperplasia (NCAH): A Multicenter Study. 79th Annual Meeting of the Endocrine Society, 1997, Minneapolis, MN, June 11-14 (Poster Presentation, P1-358)

Knochenhauer ES, Kahsar-Miller MD, Boots LR, Key TJ, Azziz R. Prevalence of Hirsutism Among Unselected Black and Caucasian Women in the Southeastern United States (U.S.) 79th Annual Meeting of the Endocrine Society, 1997, Minneapolis, MN, June 11-14 (Poster Presentation, P1-357)

Knochenhauer ES, Decanter C, Cortet-Rudelli C, Weil J, Waggoner WT, Conway-Myers BA, Dewailly D, Azziz R. Genotype and Phenotype in Women With 21-Hydroxylase (21-OH) Deficient Non-classic Adrenal Hyperplasia (NCAH). 53rd Annual Meeting of the American Society for Reproductive Medicine, 1997, Cincinnati, OH, October 18-22 (Oral Presentation, 78).

Knochenhauer ES, Decanter C, Cortet-Rudelli C, Morel Y, Conway-Myers BA, Dewailly D, Azziz R. Genotype in Women with 21-Hydroxylase (21-OH) Deficient Non-Classic Adrenal Hyperplasia (NCAH). The Endocrine Society 80th Annual Meeting, 1998, New Orleans, LA, June 23-27 (Poster Presentation, PI-369).

Azziz R, Hincapie LA, Conway-Myers BA, Knochenhauer, ES, Fox L, Cortet-Rudelli C, Dewailly D, Boots LR. Screening for 21-Hydroxylase (21-OH) Deficient Non-Classic Adrenal Hyperplasia (NCAH) in Hyperandrogenic (HA) Women: A Prospective Study. The Endocrine Society 80th Annual Meeting, 1998, New Orleans, LA, June 23-27 (Oral Presentaion, OR3-6).

Huerta R, Dewailly D, Decanter C, Knochenhauer ES, Boots LR, Azziz R. Serum 11-Hydroxylandrostenedione (11-OHA4) and 5-Androstenediol (ADIOL) as Markers of Adrenal Androgen (AA) Production: Studies in 21-Hydroxylas (21-OH) Deficient Non-Classic Adrenal Hyperplasia (NCAH). Endo ’99, the 81st Annual Meeting of the Endocrine Society, 1999, San Diego, CA, June 12-15 (Poster Presentation, P3-330).

Knochenhauer ES. The Value of Chin and Lower Abdomen Hair Growth Alone in Predicting Significant Full Body Hirsutism, IFFS ’98 16th World Congress on Fertility and Sterility and the 54th Annual Meeting of the American Society for Reproductive Medicine, 1998, San Francisco, CA, October 4-9 (Poster Presentation, P-569).

Azziz R, Black VY, Knochenhauer ES, Hines GA, Boots LR. Adrenal Androgens do not Play a Significant Role in the Oligo-Ovulation of the Polycystic Ovary Syndrome (PCOS). IFFS ’98 16th World Congress on Fertility and Sterility and the 54th Annual Meeting of the American Society for Reproductive Medicine, 1998, San Francisco, CA, October 4-9 (Poster Presentation, P-866).

Farah LA, Knochenhauer ES, Boots L, Potter HD, Azziz R. Normal Adenarche: A Longitudinal Study. 46th Annual Meeting of the Society for Gynecological Investigation, Atlanta, Ga, March 10-13, 1999, P-495

Moran C, Azziz R, Carmina E, Dewailly D, Fruzzetti F, Ibanez L, Knochenhauer ES, Marcondes JA, Mendoca BB, Pugeat M, Rhomer V, Spenser PW. Presenting Features of 21-Hydroxylase (21-OH) Deficient Non-Classic Adrenal Hyperplasia (NCAH) and Relationship to Age: A Multicenter Study. Endo ’99, the 81st Annual Meeting of the Endocrine Society, 1999, San Diego, CA, June 12-15 (Poster Presentation, P3-331).

Huerta R, Dewailly D, Decanter C, Knochehauer ES, Boots LR, Azziz R. Serum 11β-hydroxyandrostenedione and Δ5 –androstenediol as markers of adrenal androgen production: Studies in 21-hydroxylase deficient non-classic adrenal hyperplasia. Endo ’99, the 81st Annual Meeting of the Endocrine Society, 1999, San Diego, CA, June 12-15 (Oral Presentation, OR29-6).

Huerta R, Dewailly D, Decanter C, Knochehauer ES, Boots LR, Azziz R. Adrenocortical Hyper-responsivity to ACTH: A Mechanism Favoring the Normal Production of Cortisol in 21-Hydroxylase Deficient Non-Classical Adrenal Hyperplasia. Endo ’99, the 81st Annual Meeting of the Endocrine Society, 1999, San Diego, CA, June 12-15 (Oral Presentation, OR29-6).

Speiser PW, Knochenhauer ES, Dewailly D, Fruzzetti F, Marcondes JAM, Azziz R. Genotype and Phenotype In Women with Non-classic Congenital Adrenal Hyperplasia. Endo ’00, the 82st Annual Meeting of the Endocrine Society, 2000, San Diego, CA, June 21-24 (P-1654).

Traynor KD, Knochenhauer ES, Woods K, Key TJ, Boots LR, Azziz R. Prevalence of the Polycystic Ovarian Syndrome (PCOS) Among 402 Unselected Consectutive Premenopausal Women. Polycystic Ovarian Syndrome: Basic Biology and Clinical Intervention Meeting, National Institute of Enviromental Health Sciences, Research Triangle Park, NC, September 17-20, 2000

Publications:  Chapters and Reviews

Knochenhauer ES, Younger JB. Menopause. Women’s Primary Health Care: Office Practice and Procedures, 2nd Edition, McGraw Hill Inc., NY, NY, 1999 (in press).

Chang RJ, Knochenhauer ES, Slayden SM, Blackwell R. Anovulation of CNS Origin: Anatomic Causes, in Blackwell R., Carr B., eds., Textbook of Reproductive Medicine, 2nd Edition, Appleton and Lange, Stanford, CT. 1997 (Chapter 15).

Knochenhauer ES, Azziz R. Adenomyosis, Leiomyomata and Pelvic Pain, in Blackwell R., Carr B., eds., Textbook of Reproductive Medicine, 2nd Edition, Springer-Verlog, New York, NY. 1997.

Knochenhauer ES, Azziz R. Uterine Causes of Pelvic Pain, in Blackwell R., Olive D. eds., Chronic Pelvic Pain: Diagnosis and Treatment, Springer- Verlog, New York, NY. 1997.

Conway-Myers BA, Azziz R, Knochenhauer ES. Oocytes in Hyperandrogenism in Human Oocytes: From Physiology to IVF, Eds. Monduzzi Editore, 1997.

Blackwell R, Knochenhauer ES. Pituitary Tumors. Gynecology & Obstetrics, J.B. Lippincott Company, Philadelphia, Pa. 1996. (Chapter 25, vol 5:1-13).

Blackwell R, Hammond KR, Knochenhauer ES. Prolactin Disorders in Infertility, in Seibel MM eds., Infertility: A Comprehensive Text, 2nd Edition, Appleton and Lange, Philadelphia, PA. 1996. (Chapter 9 pp 155-170).

Knochenhauer ES, Blackwell RE. Operative Hysteroscopic Procedures, in Azziz R, Murphy AA eds., Practical Manual of Operative Laparoscopy and Hysteroscopy, 2nd Edition, Springer- Verlog, New York, NY. 1996 (Chapter 27 pp 286-293).

Knochenhauer ES, Azziz R. Photo and Video Documentation of Endoscopic Surgery, in Azziz R, Murphy AA eds., Practical Manual of Operative Laparoscopy and Hysteroscopy, 2nd Edition, Springer- Verlog, New York, NY. 1996 (Chapter 7 pp 49-58).

Knochenhauer ES. A Case Discussion of Hyperandrogenism. Collected Letters, International Correspondence Society Of Obstetricians and Gynecologists. 37(8) Aug. 1996.

Knochenhauer ES, Azziz R. Current Concepts in the Diagnosis and Treatment of the Hirsute Patient. Current Opinion in Obstetrics and Gynecology. 1995, 7(5):344-350.

Knochenhauer E, Azziz R., Ovarian hormones and adrenal androgens during a woman's life span. J Am Acad Dermatol. 2001 Sep;45(3 Suppl):S105-15. Review.